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Origins of an epidemic

New HIV book well researched but academic and heavy

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Virus Hunt, HIV, AIDS, gay news, Washington Blade
Virus Hunt, HIV, AIDS, gay news, Washington Blade, Dorothy H. Crawford

‘Virus Hunt’ by Dorothy H. Crawford. (Image courtesy Oxford University Press)

‘Virus Hunt: The Search for the Origin of HIV’
By Dorothy H. Crawford
Oxford University Press
$27.95
244 pages

Some things are easy to track down. Others take years, even decades.

In the new book “Virus Hunt” by Dorothy H. Crawford, you’ll see how scientists discovered the roots of HIV.

In 1981, doctors in California began noticing “rare infections … and an unusually aggressive tumor” in certain patients. Soon, the same was reported in New York, Florida and elsewhere around the country. By 1982, the disease was called AIDS.

The risk of catching AIDS seemed at first to be limited to sexually active gay men, particularly those with multiple partners. Within weeks, heroin users and hemophiliacs were added to the at-risk group, then doctors discovered that infected mothers could pass it to their children. “Fear of AIDS” became “a disease in its own right.”

By 1984, the “causative virus was identified [as human immunodeficiency virus]… and shortly thereafter the genome was sequenced …”

But where did HIV come from?

Soon after the first description of AIDS was released in 1981, Boston researchers noticed that their captive macaque population was affected with something that sounded similar.  Four years later, scientists at that research facility isolated a simian immunodeficiency virus (SIV) that had spread and mutated as animals were “unwittingly” shipped around to other facilities.

That led to the discovery that some SIVs are “closely related” to certain strains of HIV and share “between 62 and 87 percent” of their genetic sequences. It didn’t take much to see how the virus mutated, or how it leaped from animal to human, possibly via Africa’s sooty mangabey monkeys (a “natural host of the virus”), which were sometimes hunted for food.

But the question of where HIV came from needs to go back even further than 1981. A man from Memphis experienced AIDS-like symptoms back in 1952. SIVs were discovered in Icelandic sheep in 1949. Scientists, in fact, believe that SIVs are “ancient parasites” and that HIV has been “circulating in the African population since near the start of the 20th century.”

At the beginning of this book, author Dorothy H. Crawford indicates that the search for the beginnings of HIV is somewhat like a mystery. She’s absolutely correct. It is, but you need a Sherlockian PhD to understand it all.

That’s not to say that “Virus Hunt” is a bad book — that’s not the case at all. What readers will want to know, however, is that it’s very academic and heavily steeped in genetics, epidemiology and laboratory-level research. That’s great for anyone employed in those fields. For the layperson, this mystery’s not unreadable but it’s as far from relaxing entertainment as you’ll ever get.

Tackle this book, therefore, but give yourself some time to absorb it. Without that kind of consideration and careful contemplation, “Virus Hunt” will be hard to appreciate.

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PHOTOS: National Champagne Brunch

Gov. Beshear honored at annual LGBTQ+ Victory Fund event

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Gov. Andy Beshear (D-Ky.) speaks at the LGBTQ+ Victory Fund National Champagne Brunch on Sunday, April 19. (Washington Blade photo by Michael Key)

The LGBTQ+ Victory Fund National Champagne Brunch was held at Salamander Washington DC on Sunday, April 19. Gov. Andy Beshear (D-Ky.) was presented with the Allyship Award.

(Washington Blade photos by Michael Key)

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PHOTOS: Night of Champions

Team DC holds annual awards gala

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Team DC President Miguel Ayala speaks at the Night of Champions Awards Gala at the Georgetown Marriott on Saturday, April 18. (Washington Blade photo by Michael Key)

The umbrella LGBTQ sports organization Team D.C. held its annual Night of Champions Gala at the Georgetown Marriott on Saturday, April 18. Team D.C. presented scholarships to local student athletes and presented awards to Adam Peck, Manuel Montelongo (a.k.a. Mari Con Carne), Dr. Sara Varghai, Dan Martin and the Centaur Motorcycle Club. Sean Bartel was posthumously honored with the Most Valuable Person Award.

(Washington Blade photos by Michael Key)

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Television

‘Big Mistakes’ an uneven – but worthy – comedic showcase

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Taylor Ortega and Dan Levy in ‘Big Mistakes.’ (Photo courtesy of Netflix)

In the years since “Schitt’s Creek” wrapped up its six season Emmy-winning run, nostalgia for it has grown deep – especially since the still painfully recent loss of its iconic leading lady, Catherine O’Hara, whose sudden passing prompted a social media wave of clips and tributes featuring her fan-favorite performance as the deliciously daft Moira Rose. Revisiting so many favorite scenes and funny moments from the show naturally reminded us of just how much we loved it, even needed it during the time it was on the air; it also reminded us of how much we miss it, and how much it feels now like something we need more than ever.

That, perhaps more than anything else, is why the arrival of “Big Mistakes” – the new Netflix series starring, co-created and co-written by Dan Levy – felt so welcome. We knew it wouldn’t be the Roses, but it seemed cut from the same cloth, and it had David Rose (or at least someone who seemed a lot like him) in the middle of a comically dysfunctional family dynamic, complete with a mother who gets involved in town politics and a catty sibling rivalry with his sister, and still nebbish-ly uncomfortable in his own gay shoes. Only this time, instead of running a charmingly pretentious boutique, he’s the pastor of the local church, and instead of a collection of kooky small town neighbors to contend with, there are gangsters.

As it turns out, it really does feel cut from the same cloth, but the design is distinctly different. Set in a fictional New Jersey suburb, it centers on Nicky (Levy) and his sister Morgan (Taylor Ortega) – he openly gay with an adoring boyfriend (Jacob Gutierrez), yet still obsessive about keeping it all invisible to his congregation, and she drudging aimlessly through life as an underpaid schoolteacher after failing to achieve her New York dreams of show biz success – who inadvertently become enmeshed in a shady underworld when a gesture for their dead grandmother’s funeral goes horribly awry.

They’re surrounded by a crew of equally compromised characters. There’s their mother Linda (Laurie Metcalf), whose campaign to become the town’s mayor only intensifies her tendency to micromanage her children’s lives; Yusuf (Boran Kuzum), the Turkish-American mini-mart operator who pulls them into the criminal conspiracy yet is himself a victim of it; Max (Jack Innanen), Morgan’s live-in boyfriend, who pushes her for a deeper commitment and is willing to go to couples’ therapy to prove it; Annette, his mother (Elizabeth Perkins), who lends her society standing toward helping Linda’s campaign against a misogynistic opponent (Darren Goldstein); and Ivan (Mark Ivanir), the seemingly ruthless crime boss who enslaves the siblings into his network but may really be just another slave himself. It’s a well-fleshed out assortment of characters that helps our own loyalties shift and adapt, generating at least a degree of empathy – if not always sympathy – that keeps everyone from coming off as a merely “black-and-white” caricature of expectations and typecasting.

To be sure, it’s an entertaining binge-watch, full of distinctive characters – all inhabiting familiar, even stereotypical roles in the narrative – who are each given a degree of validation, both in writing and performance, as the show unspools its narrative. At the same time, it makes for a fairly bleak overall view of humanity, in which it’s difficult to place our loyalties with anyone without also embracing a kind of “dog eat dog” morality in which nobody is truly innocent – but nobody is completely to blame for their sins, anyway.

In this way, it’s a show that lets us off the hook in the sense that it places the idea of ethical guilt within a framework of relative evils, as it permits us to forgive our own trespasses by accepting its “lovably” amoral characters, each of whom has their own reasons and justifications for what they do. We relate, but we can’t quite shake the notion that, if all these people hadn’t been so caught up in their own personal dramas, none of them would have ended up in the compromised morality that they’re in.

However, it’s not some bleak morality play that Levy and crew undertake; rather, it’s more an egalitarian fantasy in which even “bad” choices feel justified by inevitability. Everybody’s motivations make enough sense to us that it’s hard to judge any of the characters for making the choices – however unwise – that they do. In a system where everyone is forced to compromise themselves in order to achieve whatever dream of self-fulfillment they may have, how can anybody really blame themselves for doing what they have to do to survive?

Of course, all things considered, this is more a relatable comedy than it is a morality play. As a comedy of errors, it all works well enough on its own without imposing an ideology on it, no matter how much we may be tempted to do so. Indeed, what is ultimately more to the point is how well this pseudo-cynical exercise in the normalization of corruption – for that is what it really about, in the end – succeeds in letting us all off the hook for our compromises.

In the end, of course, maybe all that analysis is too deep a dive for a show that feels, in the end, like it’s meant to be mostly for fun. Indeed, despite its focus on being dragged into the shady side of life, the arc of its messaging seems to be less about a moralistic urge toward making the “right” choice than it is a candid recognition that all of us are compromised from the outset, often by choices we only force upon ourselves, and that’s a refreshing enough bit of honesty that we can easily get on board.

It helps that the performances are on point, especially the loony and wide-eyed fanaticism of Metcalf – surely the MVP of any project in which she is involved – and the directly focused moral malleability of Ortega; Levy, of course, is Levy – a now-familiar persona that can exist within any milieu without further justification than its own queer relatability – and, in this case, at least, that’s both the icing on the cake and substance that defines it. That’s enough to make it an essential view for fans, queer or otherwise, of his distinctive “brand,” even if he – or the show itself – doesn’t quite satisfy in the way that “Schitt’s Creek” was able to do.

Seriously, though, how could it?

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